High Sensitivity C-Reactive Protein (Hscrp) Level And Its Association with Hyperlipidemia in Children with Nephrotic Syndrome

Abstract

Background: Hyperlipidemia is one of the important characteristics of nephrotic syndrome (NS) and it is responsible for atherosclerotic changes which can be due to vascular endothelial dysfunction that reflect the inflammatory response to tissue damage. Hyperlipidemia in childhood can induces atheroma formation among susceptible individual. Methods and materials: This cross-sectional analytical study was conducted in the Department of Pediatric Nephrology, National Institute of Kidney Diseases & Urology, Sher-E-Bangla Nagar, Dhaka and Department of Biochemistry, Dhaka Shishu Hospital, Dhaka, from December 2019 to June 2021. Data were collected by using a structured questionnaire. Collected data were analyzed by the SPSS 24. Results: Average age of all study children was 6.44±3.29 years (range: 2 - 12 years) with male predominance in both group A and group B (63.33 and 60%, respectively). Minimal change disease (MCD) was found in majority cases of group A (91.67%). Nephrotic children had significantly higher mean of total cholesterol, triglyceride, LDL, VLDL, and HDL compared to healthy children. The mean±SD (median) of serum hsCRP were higher in nephrotic children than healthy children [2.13±1.70, (1.50) vs 0.86±0.55, (0.60) mg/L, P < 0.001]. Pearson correlation analysis showed that serum hsCRP had significant moderate positive correlation with total cholesterol and LDL, weak positive correlation with triglyceride and VLDL among nephrotic children (p value <0.05). Conclusion: Serum hsCRP was found to be higher in NS children and positively correlated with hyperlipidemia. However, further studies are needed to validate these findings.