Vol. 6 No. 01 (2023)
Original Article

High Sensitivity C-Reactive Protein (Hscrp) Level And Its Association with Hyperlipidemia in Children with Nephrotic Syndrome

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Mt Anjumanara Khatun
Assistant Registrar
Mohammed Anwar Hossain Khan
Ex Professor, Department of Paediatric Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka, Bangladesh
Md Kabir Alam
Assistant Registrar, Department of Paediatric Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka, Bangladesh
Rezwana Ashraf
Assistant Registrar, Department of Paediatric Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka, Bangladesh
Habiba Jesmin
Assistant Registrar, Department of Paediatric Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka, Bangladesh
Md Reaz Uddin
Assistant Registrar, Department of Paediatric Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka, Bangladesh
Salma Sadiya
Assistant Professor, Department of Biochemistry, Bangladesh Institute of Child Health, Dhaka, Bangladesh
Mohammad Tareq Imtiaz
Resident Phase B, Department of Paediatric Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka, Bangladesh
Subrata Roy
Senior Consultant, Department of Paediatrics, Directorate General of Health Services (DGHS), Dhaka, Bangladesh
Sabrina Akter
Assistant Professor, Department of Paediatric Nephrology, Ad-din Sakina Medical College Hospital, Jashore, Bangladesh
Sumon Dhar
Assistant Registrar, Department of Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka, Bangladesh

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Abstract

Background: Hyperlipidemia is one of the important characteristics of nephrotic syndrome (NS) and it is responsible for atherosclerotic changes which can be due to vascular endothelial dysfunction that reflect the inflammatory response to tissue damage. Hyperlipidemia in childhood can induces atheroma formation among susceptible individual. Methods and materials: This cross-sectional analytical study was conducted in the Department of Pediatric Nephrology, National Institute of Kidney Diseases & Urology, Sher-E-Bangla Nagar, Dhaka and Department of Biochemistry, Dhaka Shishu Hospital, Dhaka, from December 2019 to June 2021. Data were collected by using a structured questionnaire. Collected data were analyzed by the SPSS 24. Results: Average age of all study children was 6.44±3.29 years (range: 2 - 12 years) with male predominance in both group A and group B (63.33 and 60%, respectively). Minimal change disease (MCD) was found in majority cases of group A (91.67%). Nephrotic children had significantly higher mean of total cholesterol, triglyceride, LDL, VLDL, and HDL compared to healthy children. The mean±SD (median) of serum hsCRP were higher in nephrotic children than healthy children [2.13±1.70, (1.50) vs 0.86±0.55, (0.60) mg/L, P < 0.001]. Pearson correlation analysis showed that serum hsCRP had significant moderate positive correlation with total cholesterol and LDL, weak positive correlation with triglyceride and VLDL among nephrotic children (p value <0.05). Conclusion: Serum hsCRP was found to be higher in NS children and positively correlated with hyperlipidemia. However, further studies are needed to validate these findings.

Published 28-11-2023

Keywords

  • hsCRP,
  • Nephrotic Syndrome,
  • Hyperlipidemia

How to Cite

1.
Khatun MA, Khan MAH, Alam MK, Ashraf R, Jesmin H, Uddin MR, Sadiya S, Imtiaz MT, Roy S, Akter S, Dhar S. High Sensitivity C-Reactive Protein (Hscrp) Level And Its Association with Hyperlipidemia in Children with Nephrotic Syndrome. The Insight [Internet]. 2023 Nov. 28 [cited 2024 Apr. 23];6(01):12-20. Available from: https://bdjournals.org/index.php/insight/article/view/331