Antibiotic Resistance among Uropathogens

Abstract

Introduction: Urinary tract infections are the most common human infection. Resistance of uropathogen to antibiotic is now a global problem. Variation in resistance pattern of different antibiotic are known to occur in different geographic area as well as in the same country. Given this back ground the aim of this study was to identify common uropathogen and their résistance profile among the patient at the OPD of a private hospital in Khulna. Materials and method: Appropriate urine specimens of all suspected cases of UTI are processed in the laboratory for detection of significant bacteriuria. Bacterial uropathogens isolated were identified by standard biochemical tests and antibiotic susceptibility test to antibiotics was carried out on them by using Kirby-Bauer disc diffusion technique. Results: Among 77 uropathogen, Escherichia coli accounted for 73 (94.80%) of all isolate. Meropenem-73(100%), netilmycins-71(97.25%), amoxicillinclavulanic acid-67(91.77%), gentamycin-64(87.66%), nitrofuantoin-63(86.29), levofloxacin-(83.55%) and ceftazidime-59 (80.81%) showed sensitivity to E. coli. In contrast Nalidixic acid- 62(84.93%), Cefachlor62(84.93%) Cefuroxime- 47(64.38), Cefixime- 45(61.64%) and ciprofloxacin- 34(46.57%) were resistant to E. coli. Conclusion: Regular monitoring of uropathogen and antibiotic susceptibility is needed to determine the appropriate empirical antibiotic treatment and overcoming drug resistance.