SARS Coronavirus 2 (SARS-CoV-2) starting from Wuhan province of China in December 2019 spreads rapidly worldwide that had infected more than 16 million individuals and caused more than 656 000 deaths worldwide by July 29, 2020. Coronavirus disease 2019 (COVID-19) is an emerging respiratory infectious disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Till now there is no effective treatment for COVID-19 and the virus spreads easily and the majority of the world's population is still vulnerable to it. So, a safe and effective vaccine against COVID-19 is urgently needed.