The Relationship between Insulin Demand and Fetomaternal Outcome in Women with Diabetes Mellitus and GDM

Abstract

Background: Diabetes mellitus is an important disorder in pregnancy which places. Mother and fetus at risk during current pregnancy and also has serious implications for their long term well-being. Pre conceptional councelling was implanted in pregnancy with diabetics mellitus. Methods and materials: From January 2006 to December 2008, this prospective study was carried out at the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine, and Metabolic Disorders (BIRDEM), Dhaka. Over 150 people with diabetes were recruited for the study. Pre-gestational diabetes mellitus (PGDM) - group A, and gestational diabetes mellitus (GDM) - group B were the two groups of women into whom they were split. Results: In group A, insulin requirement was 30-75 IU in 30 (50%), <30 IU in 17 (28%) and >75 IU in 13 (22%) women, and in group B was <30 IU in 36 (60%), 30-75 IU in 16 (27%) and >75 IU in 8(13%) women. In both groups, hypoglycemia was high among babies born to mothers on insulin <30 IU and >75 IU, and hyperbilirubinemia was high among babies born to mothers on insulin dose 30-75 IU and >75 IU and <30 IU. In group A, RDS was high among babies born to mothers on insulin dose <30 IU (69.2%), in group B insulin dose 30-75 IU. Conclusion: In diabetes pregnancies, proper blood sugar management can lower the risk of congenital defects, as well as the morbidity and mortality of both the mother and the fetus.