Elevated Homocysteine Levels might be the predictor of Gestational Diabetes Mellitus

Abstract

Objective: The main goal of this study is to assess the homocysteine levels and its relation with gestational diabetes mellitus in pregnant women. Methods:  This case control study was conducted on the pregnant women between 24 weeks to 40 weeks of gestational period attending the inpatients and outpatient department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University, Dhaka from July 2011 to June 2013. Pregnant women between 24 weeks to 40 weeks of gestation attending the inpatient and outpatient department of Obstetrics and Gynecology, BSMMU hospital were included in the study.Microsoft Excel and SPSS version 22 used for statistical analysis. Result: The mean levels of homocysteine (Hcy) in Gestational Diabetes Mellitus (GDM) group were significantly higher but folic acid and vit B12 were significantly lower. Hcy levels were decreased in both groups after six weeks folic acid but decrease in Hcy for group 5mg was significantly more than 1mg group. Conclusion: High-dose folic acid can lower Hcy levels more effectively than low-dose folic acid, and it could be a safe, easy, and economical remedy to avoid serious pregnancy problems.