Vol. 6 No. 01 (2023)
Original Article

Efficacy of Granulocyte Colony Stimulating Factor (G-CSF) to Manage Neutropenia in Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin’s Lymphoma (NHL)

Full Article

PDF
Nayeema Ferdous Shanta
Junior Consultant of Paediatrics, Shibchar Upazila Health Complex, Madaripur, Bangladesh
Sabira Rahman
Consultant, Police Hospital, Dhaka, Bangladesh
Saima Hossain
Registrar, Institute of Child and Mother Health, Dhaka, Bangladesh
Saifa Lubna Mili
Registrar, Ad-din Womens Medical College, Dhaka, Bangladesh
Mashura Morshed
Consultant, Department of Paediatrics, Dhaka Medical College, Dhaka, Bangladesh

Find this Article on:

Abstract

Introduction: Leukemia and NHL are the two most common malignancies in childhood. Nowadays children with malignant diseases have an excellent chance of survival around 75%. The incidence of neutropenia depends upon several factors including dose intensity, chemotherapy, the prior history of the patient, and the presence or absence of co-morbid condition. Aim of the study: This study aimed to assess the effect of G-CSF on neutropenia in patients of ALL and NHL and to see the duration of fever as compared to the control group. Methods and Materials: Children from 2 years to 12 years of age who had absolute neutrophil count (ANC) <500 /cumm, and attended in Paediatric Hematology and Oncology Department of DMCH, from July 2012 to July ’13 were selected purposively. Data analysis was carried out with the help of SPSS (Statistical Package for Social Science) Windows software program. Results: Among 30 patients, 22 ALL patients and 8 NHL patients were included in group A, and 6 ALL patients and 4 NHL patients were included in group B. There was male predominance. The mean ANC was found 710.73±213.3/cumm in group A and 531±307.9/cumm in group B. The mean difference was statistically significant (p<0.05) between the two groups. groups. The mean duration of fever was found 11.07±3.08 days in group A and 13.6±4.03 days in group B which was statistically significant (p<0.05) between the two groups. Conclusion: This study concludes that G-CSF therapy significantly increases the absolute neutrophil count reduces the duration of fever and therefore lowers the infection rate.

Published 28-11-2023

Keywords

  • Granulocyte Colony Stimulating Factor (G-CSF),
  • Neutropenia, Acute Lymphoblastic Leukemia (ALL),
  • Non-Hodgkin’s Lymphoma (NHL)

How to Cite

1.
Shanta NF, Rahman S, Hossain S, Mili SL, Morshed M. Efficacy of Granulocyte Colony Stimulating Factor (G-CSF) to Manage Neutropenia in Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin’s Lymphoma (NHL). The Insight [Internet]. 2023 Nov. 28 [cited 2024 Apr. 23];6(01):198-207. Available from: https://bdjournals.org/index.php/insight/article/view/355