Vol. 6 No. 01 (2023)
Original Article

Clinical and Biochemical Studies of the Gender Specific Risk Factors for Cssardiovascular Disease in Patients of Type 2 Diabetes with NAFLD

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Bidhan Krishna Sarker
Lecturer, Department of Pharmacology and Therapeutics, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
Sangita Devi
Consultant, Department of Gynaecology and Obstetrics, Jainta Upazila Health Complex, Sylhet, Bangladesh
Sonia Akter
Assistant Professor, Department of Pharmacology and Therapeutics, Ashiyan Medical College, Dhaka, Bangladesh
Tasnova Islam Chy
Assistant Professor and Head, Department of Pharmacology and Therapeutics, Southern Medical College and Hospital, Chittagong, Bangladesh
Md Shahab Uddin
Rtd. Professor & Head, Department of Medicine, Cumilla Medical College & Hospital, Cumilla, Bangladesh

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Abstract

Introduction: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). Additionally, the co-occurrence of non-alcoholic fatty liver disease (NAFLD) further exacerbates this risk. While numerous studies have explored the pathophysiological mechanisms underlying CVD in T2DM, there is a notable paucity of research focusing on the gender-specific nuances of this complex interplay.  Methods & Materials: A hospital-based observational study was carried out in the Department of Medicine, Cumilla Medical College and Hospital, Bangladesh, from 1st July to 31st December 2012. Fifty admitted patients of type2 diabetes with NAFLD were included in this study.  Results: Out of 50 patients, 18(36%) were males and 32(64%) were females, with mean age 58.89 ± 8.38 and 54.6 ± 10.1 years respectively. The prevalence of hypertension (p <0.0001), obesity (measured by BMI) (p<0.0001), central obesity (measured by waist circumference and waist hip ratio) (p<0.0001), higher triglyceride levels (p<0.0001), higher LDL-C level (p<0.0001) and lower HDL-C levels (p<0.0001) were significantly higher among the study population. On statistical analysis, we found increasing grades of NAFLD were significantly associated with hypertension (p=0.0083), obesity (p=0.0006), increasing levels of total cholesterol (p<0.0001), ALT (p<0.0001), AST (p<0.0001) and ALP (p<0.0001). Conclusion: In our study we exposed that males exhibited a significantly higher propensity for smoking and possessed higher Body Mass Index (BMI) compared to females. On the other hand, females were more inclined to have higher Waist-to-Hip Ratios (WHRs) overall.

Published 28-11-2023

Keywords

  • Non-alcoholic fatty liver disease,
  • cardiovascular disease,
  • metabolic syndrome,
  • cardiovascular risk factors

How to Cite

1.
Sarker BK, Devi S, Akter S, Chy TI, Uddin MS. Clinical and Biochemical Studies of the Gender Specific Risk Factors for Cssardiovascular Disease in Patients of Type 2 Diabetes with NAFLD. The Insight [Internet]. 2023 Nov. 28 [cited 2024 Apr. 23];6(01):75-86. Available from: https://bdjournals.org/index.php/insight/article/view/339