Vol. 7 No. 01 (2023)
Original Article

Observation of Serum Ascites Albumin Gradient Values among Children with Ascites

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Most Samsun Nahar Sumi
Assistant Professor, Department of Paediatric Neurology, National Institute of Neuroscience and Hospital, Dhaka, Bangladesh
Nahid E-Subha
Assistant Professor, Department of Pediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical College, Faridpur, Bangladesh
Farhana Shams
Assistant Professor, Department of Microbiology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh
Md Ahsan Habib
Associate Professor, Department of Colorectal Surgery, Dhaka Medical College Hospital, Dhaka, Bangladesh
Razia Sultana
Assistant Professor, Department of Paediatric Neurology, Medical College for Women and Hospital, Dhaka, Bangladesh
Mosammat Shameem Ara Begum
Assistant Professor, Department of Pediatrics, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
Sarah Alam
Junior Consultant, Department of Pediatric Neurology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh

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Abstract

Introduction: The serum ascites albumin gradient (SAAG) represents the difference in concentration between serum albumin and ascitic fluid albumin. Various studies have consistently shown a direct correlation between SAAG and portal pressure. A high SAAG value is indicative of portal hypertension. Aim of the study: This study aimed to observe the serum ascites albumin gradient values among children with ascites. Methods and Materials: This cross-sectional study was conducted in the Dhaka Medical College Hospital (DMCH) and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from Jan 2009 to July 2009. A total of 40 consecutive patients with ascites were selected as study subjects using a purposive sampling technique. The data were analyzed using SPSS version 23.0. Results: In this study, 85% of nephrotic syndrome cases had a serum ascites albumin gradient (SAAG) < 1.1 gm/dl, while 15% had SAAG ≥1.1 gm/dl. For chronic liver disease, SAAG was ≥1.1 gm/dl in 92.85% and < 1.1 gm/dl in 7.15%. SAAG was consistently < 1.1 gm/dl in disseminated tuberculosis and protein-losing enteropathy but ≥1.1 gm/dl in congestive cardiac failure. Mean SAAG values in nephrotic syndrome, chronic liver disease, disseminated tuberculosis, protein-losing enteropathy, and congestive cardiac failure were 0.72±0.37, 1.63±0.49, 0.68±0.25, 1±0, and 2.30±0, respectively, with highly significant differences (P<0.001). Conclusion: The serum ascites albumin gradient (SAAG) demonstrates higher sensitivity and specificity, along with a higher positive predictive value, compared to ascitic fluid total protein concentration in the differential diagnosis of ascites. The SAAG value can serve as a reliable screening test in ascitic patients, with specific tests being conducted as needed for individual patients.

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Published 10-02-2024

Keywords

  • Serum ascites albumin gradient,
  • SAAG,
  • Ascitic fluid albumin,
  • Nephrotic syndrome,
  • Chronic liver disease,
  • Children
  • ...More
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How to Cite

1.
Sumi MSN, E-Subha N, Shams F, Habib MA, Sultana R, Begum MSA, Alam S. Observation of Serum Ascites Albumin Gradient Values among Children with Ascites. Planet (Barisal) [Internet]. 2024 Feb. 10 [cited 2024 Jul. 25];7(01):67-76. Available from: https://bdjournals.org/index.php/planet/article/view/407