Correlation of Serum Creatinine with Child-Pugh Score among Patients with Decompensated Cirrhosis of Liver

Abstract

Introduction: Child–Pugh score can reliably predict disease severity among patients with decompensated liver cirrhosis, but a cheaper and readily available screening method like serum creatinine could lead to faster prediction of change in disease severity and better prognosis. Objectives: Present study aims to determine if there is any correlation of serum creatinine with Child-Pugh score among patients with decompensated cirrhosis of liver. Methods & Materials: This cross-sectional study was conducted at Sher-E-Bangla Medical College Hospital, Barisal, from July 2015 to December 2015, on 100 patients suffering from decompensated cirrhosis of liver. Adult patients of either sex, age ≥ 18 years, were enrolled in the study through purposive sampling technique. Results: Out of the 100-study population, 34% were from age group 51 – 60 years. Mean age was 58.49 ± 6.74 years. Study population was male (76%) predominant. HBV was responsible for liver cirrhosis among 42% of the population. During admission, 43% had tense ascites, followed by 21% with encephalopathy and 19% with variceal bleeding. Ascites was the most common (69%) first sign of decompensation, followed by variceal bleeding at 31%. Majority (44%) of the study population was classified as class C, followed by 37% as class B and 19% as class A. No statistically significant (p > 0.05) relation between serum creatinine level and Child-Pugh score was found.Conclusion: Most patients of decompensated cirrhosis have shown some degree of renal impairment, but the degree of renal impairment did not show significant relationship with Child-Pugh score. Degree of renal impairment cannot be used as a predictor for severity of liver disease.