Assessment of Lipid profile variation in Pre and Post-Menopausal Women in relation with Weight — Study in Rural area

Abstract

Introduction: Menopause is a permanent physiological state with cessation of menstruation due to loss of ovarian function and reduction in the production of estrogen.¹. The lipid profile changes during menopause for a variety of reasons. Objectives: The aim of the study was to evaluate the lipid profile variation in pre  and post-menopausal women in relation with weight. Methods: This Prospective observational study was carried out in private chamber in Rupganj Upazila in Narayanganj, Bangladesh during the period of July 2021 to June 2022. The study population consisted of 92 female, among them 46 are apparently healthy pre-menopausal women between the age limits of 20-48 years and 46 are post-menopausal women between the age limits of 45-70 years. Statistical analyses of the results were obtained by using windows-based Microsoft Excel and Statistical Packages for Social Sciences (SPSS-24). Results: According to this study, the serum levels of TC, TG and LDL-C were significantly higher in post-menopausal women in comparison to pre-menopausal, irrespective of BMI (P < 0.05). Similarly, HDL-C levels were significantly lower in post-menopausal women as compared with pre-menopausal women of similar BMI (P < 0.05). Conclusion: As compared to the reproductive age group, the  postmenopausal women had a rise in TC, TGs and LDL-C level, and a decrease in HDL-C level. These alterations are independent of BMI, since they were observed in overweight women in both pre and post-menopausal women.