Beyond the Fever – A Prospective Analysis of Acute Neuropsychiatric Morbidity and Sleep Disturbances During Epidemic Dengue Outbreaks

Open Access

Abstract

Background: Dengue outbreaks are intensifying globally, yet the focus remains largely on hematological parameters. This study sought to explore the "hidden" neuropsychiatric morbidity and sleep disturbances during a historic epidemic in Bangladesh. Methods & Materials: A prospective observational analysis was conducted on 292 laboratory-confirmed cases at BIRDEM General Hospital, Dhaka. Data on classic clinical symptoms, diagnostic markers (NS1/IgM/IgG), and acute mental health status were evaluated. Results: Beyond the hallmark febrile symptoms, significant psychiatric morbidity was observed: 7.9% of patients experienced acute irritability, and 7.9% suffered from insomnia. Despite the absence of prior psychiatric history, low mood (3.8%) and lack of interest (4.1%) were documented during the acute phase. Conclusion: Acute dengue infection exerts a measurable neuropsychiatric toll. Identifying these symptoms is crucial for holistic patient care and understanding the expanded clinical spectrum of the virus.