Vol. 10 No. 01 (2026), Original Article
Vol. 10 No. 01 (2026)
Original Article

Antimicrobial Susceptibility Pattern of Gram-Negative Bacterial Isolates in Chronic Mucosal Otitis Media
Open Access
Open Access

Rezaul Karim
Research Officer, Department of Otolaryngology & Head Neck Surgery, National Institute of ENT, Tejgaon, Dhaka, Bangladesh
https://orcid.org/0009-0005-6173-618X (unauthenticated)
Rifat Hassan
Assistant Professor, Department of Otolaryngology & Head Neck Surgery, National Institute of ENT, Tejgaon, Dhaka, Bangladesh
https://orcid.org/0009-0004-6614-8021 (unauthenticated)
Kamrul Hasan Mollik
Assistant Professor, Department of ENT, National Institute of ENT, Tejgaon, Dhaka, Bangladesh
https://orcid.org/0009-0001-6839-9260 (unauthenticated)
Ashraful Islam
Assistant Registrar, Department of Otolaryngology & Head Neck Surgery, National Institute of ENT, Tejgaon, Dhaka, Bangladesh
https://orcid.org/0009-0001-0387-8797 (unauthenticated)
Mahbobul Haque
Assistant Professor, Department of ENT, General Hospital, Faridpur, Bangladesh Attachment -National Institute of ENT, Tejgaon, Dhaka, Bangladesh
https://orcid.org/0009-0004-8671-0974 (unauthenticated)
Rahat Tanvir Anwar
Assistant Registrar, Department of Otolaryngology & Head Neck Surgery, National Institute of ENT, Tejgaon, Dhaka, Bangladesh
https://orcid.org/0009-0005-7659-1710 (unauthenticated)
Published 19-08-2026

DOI: 10.5281/zenodo.22012088


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Keywords

Antimicrobial Susceptibility Pattern
Gram-Negative Bacterial
Chronic Mucosal Otitis Media

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1.
Antimicrobial Susceptibility Pattern of Gram-Negative Bacterial Isolates in Chronic Mucosal Otitis Media. Planet (Barisal) [Internet]. 2026 Aug. 19 [cited 2026 Aug. 26];10(01):185-8. Available from: https://bdjournals.org/planet/article/view/1385
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Abstract

Background: Chronic mucosal otitis media is a long-lasting middle ear infection in children from developing nations, primarily due to Gram-negative bacteria, particularly Pseudomonas aeruginosa, which shows rising resistance to ampicillin and cephalosporins, whereas ciprofloxacin, aminoglycosides, and carbapenems continue to be more effective. Insufficient information in Bangladesh indicates a necessity for improved surveillance. This study assesses the antimicrobial resistance of Gram-negative isolates in a tertiary care facility. Methods & Materials: This cross-sectional research conducted at Dhaka Medical College Hospital, Bangladesh (2019 and 2022-2023) involved patients between the ages of 6 and 55 with chronic mucosal otitis media. Aural swabs were cultured on blood agar and MacConkey agar, and isolates were identified using standard techniques. Antimicrobial susceptibility was assessed through the Kirby-Bauer disk diffusion technique, followed by descriptive statistical analysis conducted after obtaining ethical approval and informed consent. Results: Out of 83 isolates, 58 (69.9%) were Gram-negative, predominantly Pseudomonas aeruginosa (62.1%), and including Klebsiella, E. coli, and Proteus. P. aeruginosa exhibited the greatest sensitivity to gentamicin and piperacillin-tazobactam but demonstrated significant resistance to ciprofloxacin and cephalosporins. Other isolates demonstrated higher susceptibility to meropenem, amikacin, and piperacillin-tazobactam while showing significant resistance to ampicillin. Conclusion: Chronic mucosal otitis media was primarily dominated by gram-negative bacteria, especially Pseudomonas aeruginosa, which showed significant resistance to standard antibiotics; however, carbapenems, aminoglycosides, and piperacillin-tazobactam proved to be the most effective treatments. Therapy and monitoring guided by culture are essential.
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