Vol. 6 No. 01 (2022)
Original Article

The Relationship of COVID-19 with Severe Asthma Patients Treated with Biologics

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Md. Monharul Islam Bhuiya
Assistant Professor, Department of Medicine, Sylhet Womens Medical College, Sylhet, Bangladesh
Mahjuba Umme Salam
Professor and Head, Department of Medicine, Sylhet Womens Medical College, Sylhet, Bangladesh
Jakaria Mahmud
Assistant Professor, Pulmonologist, Sylhet MAG Osmanli Medical College, Sylhet, Bangladesh
Sahed Ahmed
Associate Professor (CC), Department of Medicine, Sylhet Womens Medical College, Sylhet, Bangladesh
Must. Khaleda Pervin Mita
Lecturer, Department of Anatomy, Sylhet MAG Osmanli Medical College, Sylhet, Bangladesh

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Abstract

Objective: To evaluate the relationship of COVID-19 withsevere asthma patients treated with biologics. Method:This prospective cohort study done at tertiary medicalhospital where 150 patients with severe asthma included assample. A standardised questionnaire was administered byphone or during outpatient visits and information aboutsymptoms suggestive of COVID-19, hospital admission forCOVID-19 and diagnostic testing through nasopharyngealswab (PCR) or serology (SARS-CoV-2 IgG) was obtained.During study based they divided two types of treatmentstudy group . Where patients who were treated with steroidbelong to no bilogics group, n=50 where those who aretreated with biologics, n =100. belong to Anti-IL5 or antiIL5R. Results: During the study, majority were belong to>50 years age group, 66.67% and 32% had diabetesfollowed by 23% had hypertension, 15% had Ischemicheart disease and 30% were obese. In non biologic group,10 cases had PCR positive where in other biologics group PCR positive cases were low. Inaddition during biologics usage 42% treated with Omalizumab followed by 20.69% caseswere treated with Anti-IL5, 50% treated with Mepolizumab, 17.24% treated with Reslizumaband 12.07% treated with Dupilumab. Besides that, higher number daily oral corticosteroidintake cases seen in non biologics group, 15% rather than biologics. Apart from that meanhospital stay duration or o2 therapy cases higher in non-biologics group. Conclusion: A tinynumber of COVID-19 instances were discovered within this study among adult patients withsevere asthma, none of which resulted in death or a very severe clinical course. Treatmentwith biologics for severe allergic or severe eosinophilic asthma was not linked to anincreased risk of SARS-CoV-2 infection or more severe COVID-19 infection.

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Published 15-08-2022

Keywords

  • Covid-19,
  • severe asthma,
  • biologics

How to Cite

1.
Bhuiya MMI, Salam MU, Mahmud J, Ahmed S, Mita MKP. The Relationship of COVID-19 with Severe Asthma Patients Treated with Biologics. Planet (Barisal) [Internet]. 2022 Aug. 15 [cited 2023 Feb. 4];6(01):32-7. Available from: https://bdjournals.org/index.php/planet/article/view/167