Association of First Trimester Serum Albumin, Creatinine and Uric Acid Level as Early Prediction of Hypertensive Disorders: An Observational Study in a Tertiary Care Hospital in Bangladesh

Abstract

Background: hypertensive disorders of pregnancy are a common cause of both maternal and perinatal morbidity and mortality in both developed and developing countries. Objective: this study aims to identify the association of first trimester serum albumin, creatinine, and uric acid level as early prediction of hypertensive disorders in pregnant women of a tertiary care hospital in bangladesh. Method: a prospective study was carried out among 119pregnant women in the outpatient department of obstetrics and gynaecology, bangabandhu sheikh mujib medical university, bangladesh, from june 2005 july 2006. Details and data obtained from medical records section were analyzed. Results: in our study, 119 women were included. Among them pe developed in 10 patients and 109 patients were normotensive. The mean age was 25.485.26 vs 25.603.89 in control vs pe subjects. At booking the mean sbp were 104.4010.67 vs 121.506.26, mean dbp were 65.736.41 vs 68.005.87, mean map were 77.665.28 vs 78.626.39, and mean map at 3rd trimester was 78.626.39 vs 115.008.64 in control and pe subjects. The mean systolic blood pressure during third trimester of the study group was 104.4010.67 in control vs 135.0011.79 in pe subjects. The mean diastolic blood pressure during 3rd trimester of the study group was 65.736.41 in control vs 105.007.82 in pe subjects. Mean arterial blood pressure at 3rd trimester of the study group were 78.686.39 in control vs 115.008.64 in pe. Conclusion: single estimations of serum uric acid, creatinine and serum albumin concentrations associated with early pregnancy are of little value in the prediction of subsequent development of hypertensive disorders in pregnant women.