Preterm PROM Inflammation Marker — Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR)

Abstract

Introduction: PPROM delivery is a significant event of obstetrical units of different centers. Usually, the feomaternal outcome related to this complication is not very satisfactory. Therefore, postulating any dependable investigation that can predict the forthcoming PPROM is essential. Methods and materials: The study place was the Department of Obstetrics and Gynaecology, Sir Salimullah Medical College (SSMC) & Mitford Hospital (MH), Dhaka, Bangladesh, from May 2019 to October 2019. Results: It was a case-control study. All mothers were selected by purposive sampling who were preterm PROM as cases. Age-matched non-preterm PROM pregnant women at term were included as control. Afterward, eligibility criteria were used to scrutinize and 200 mothers were included; 100 as cases, and the other 100 as  control. A pre-tested, observation-based, peer-reviewed data collection regarding clinical, biochemical, and surgical profiles were done and recorded. The P-value was determined by the chi-square test (categorical variables) and the student’s t-test (continuous variables). The p-value was significant at <0.05. Conclusions: The mean age of 100 patients from the case was 24.39±2.81 (age range: 18-36) years, and that of the control, like 100 normal pregnant women, was 24.31±2.34 (age range: 19-35). (P=0.49). Correlation analysis revealed that PLR levels were positively correlated with NLR (n=0.11, p=0.29). Therefore, NLR and PLR outcomes accurately and specifically predict spontaneous preterm birth. Preterm birth can be predicted, allowing for delicate and effective management of the pregnancy process.