Concurrent 2-D Versus 3d-Crt Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of Uterine Cervix

Abstract

Introduction: Concurrent chemoradiotherapy is the standard treatment of locally advanced carcinoma of uterine cervix. Traditionally, External Beam Radiotherapy (EBRT) is given by two dimensional radiotherapy in which surrounding normal tissue gets more radiation and causes significant toxicities. To overcome these toxicities EBRT is given by three-dimensional conformal radiotherapy technique. Objective: To compare the effectiveness and toxicities of treatment with concurrent three dimensional conformal radiotherapy and concurrent two dimensional radiotherapy in locally advanced squamous cell carcinoma of uterine cervix. Methods and Materials: This quasi experimental study was conducted from January 2018 to June 2019. A total number of 60 patients of locally advanced squamous cell carcinoma of uterine cervix allocated equally in Arm A and Arm B. Patients of Arm A received 3D-CRT concurrent chemoradiotherapy and those of the Arm B received 2D-RT concurrent chemoradiotherapy followed by Intracavitary radiotherapy for both Arms . Every patient was assessed weekly during radiotherapy and then at 6^th, 12^th and 24^th weeks after radiotherapy. Results: At six months after completion of radiotherapy, 29 (96.7%) and 26 (86.7%) patients of Arm A and B had complete response respectively (p≥0.05). Among acute toxicities, significant (Grade 3) gastrointestinal toxicities were seen in Arm B (P<0.05). Grade 3 dermatological toxicity were observed in 1 (3.3%) and 6 (20%) patients of the Arm A and B respectively (p<0.05). Conclusion: The patients of 3D-CRT arm showed better response arithmetically. Also, there was an observable significant reduction of toxicities in the 3D-CRT arm.