Vol. 6 No. 01 (2022)
Original Article

Effects of Sucralfate in the Control of Oral Mucositis in Patients with Head and Neck Cancers Undergoing Radiotherapy

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ANM Mainul Islam
Assistant professor, Department of radiotherapy, Sher-E-Bangla Medical College, Barishal
Rumana Afroz Majumdar
Assistant professor (Current charge), Department of Oncology, Bangladesh Medical College, Dhaka
Shirajush Salekin
Medical officer, Department of radiotherapy, Sher-E-Bangla Medical College, Barishal
Farhana Khanam
Medical officer, Department of radiotherapy, Sher-E-Bangla Medical College, Barishal
Shah Md. Fazlay Rabby Khan
Junior consultant, Ortho Surgery, Sadar Hospital, Jhalokathi
Md. Mohsin Howlader
Radiotherapist, Sher-E-Bangla Medical College Hospital, Barishal

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Abstract

Introduction: Head and neck cancers (HNC) are common in our country. The patients with locally advanced disease are treated with combined modality approaches. Oral mucositis is one of the most common complications of radiotherapy in HNC which can lead to chronic sequelae and interrupt radiation treatment.  Objectives: The aim of this study was to evaluate the effects of sucralfate in the control of radiation induced mucositis. Methods and materials: This quasi-experimental study was carried out among 60 locally advanced head and neck cancer patients. Every alternate patient was assigned in two groups of 30 patients. One group was treated with basic oral care and other group was treated with sucralfate in addition to basic oral care. Patients were examined weekly. Grade of mucositis was evaluated according to WHO grading scale. Results: It was found that addition of sucralfate significantly delayed the onset of mucositis. The overall percentage of mucositis (grade 1 to 4) in group without sucralfate and in group with sucralfate was 100% and 86.67% respectively. This study also revealed that addition of sucralfate significantly reduced the occurrence of weight loss in patients during radiation (p value = o.o36). 26.7% of patients in group without sucralfate required minimum 3 days of gap due to illness, whereas, 6.7% in patients of sucralfate group required that type of gap (p value = 0.037).  Conclusion: This study demonstrated that sucralfate is of beneficial value in minimizing radiation induced oral mucositis.

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Published 15-08-2022

Keywords

  • Head and neck cancers, Radiotherapy, Neo-adjuvant chemotherapy, Mucositis, Sucralfate.

How to Cite

1.
Islam AM, Majumdar RA, Salekin S, Khanam F, Khan SMFR, Howlader MM. Effects of Sucralfate in the Control of Oral Mucositis in Patients with Head and Neck Cancers Undergoing Radiotherapy. Planet (Barisal) [Internet]. 2022 Aug. 15 [cited 2023 Feb. 4];6(01):146-52. Available from: https://bdjournals.org/index.php/planet/article/view/158