Vol. 6 No. 01 (2023)
Original Article

Impact of Calcium and Vitamin D Supplementation on Bone Mineral Content in Children Diagnosed with Thalassemia

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Umme Nusrat Ara
Medical Officer, Department of Paediatric Hematology and Oncology, Bangladesh Shishu Hospital & Institute, Dhaka
Zamil Ahmed Manik
Assistant Professor, Department of paediatrics, Paediatrics of Child & Mother Health, Matuail, Dhaka
FarzanaAlam Mou
Specialist, Hematology and Bone Marrow Transplant Unit, Evercare Hospital, Dhaka
Tapash Chowdhury
Specialist, Department of Paediatrics and Neonatology, Bangladesh Specialized Hospital, Dhaka
Tania Sultana
Medical Officer, Department of Paediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka
Sharmin Akhter
Staff Clinical Physician, Department of Hematology, Asgor Ali Hospital, Dhaka

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Abstract

Introduction: This study aimed to assess the effect of vitamin D and calcium supplementation on osteoprotection in children with thalassemia. Methods and Materials: Twenty-nine children aged 5-18 years were administered oral vitamin D (600 IU/day) and calcium (500 mg/day) for a duration of one year. Dual-energy X-ray absorptiometry (DXA) was used to measure bone mineral content at the beginning of the study and after 12 months. Additionally, serum 25-hydroxy vitamin D, Serum parathyroid hormone, calcium and phosphate levels were assessed at baseline, 6 months, and 12 months. Results: The mean (SD) bone mineral content increased significantly from the baseline value of 9.3 g to 11.7 g. Similarly, the mean (SD) vitamin D level increased from the initial value of 17.0 ng/mL to 24.7 ng/mL. Conclusions: Supplementing with oral vitamin D and calcium enhances bone mineral content in children diagnosed with thalassemia over a period of one year.

Published 28-11-2023

Keywords

  • Thalassemia,
  • Osteoporosis,
  • Bone density,
  • Cholecalciferol,
  • Absorptiometry

How to Cite

1.
Ara UN, Manik ZA, Mou F, Chowdhury T, Sultana T, Akhter S. Impact of Calcium and Vitamin D Supplementation on Bone Mineral Content in Children Diagnosed with Thalassemia . The Insight [Internet]. 2023 Nov. 28 [cited 2024 Apr. 23];6(01):233-42. Available from: https://bdjournals.org/index.php/insight/article/view/359