Distribution of eGFR Across Age, Sex, and Rh Factor Subgroups among Chronic Kidney Disease Patients in a Tertiary Care Hospital

Open Access

Abstract

Introduction: Chronic kidney disease (CKD) is a progressive condition marked by a gradual decline in kidney function, often leading to end-stage renal disease if not detected and managed early. Estimating glomerular filtration rate (eGFR) is a key clinical tool for assessing kidney function and staging CKD. Methods & Materials: This cross-sectional observational study was conducted in department of Nephrology, National Institute of Kidney Diseases & Urology, Dhaka, Bangladesh, from January 2022 to June 2022, to evaluate the distribution of estimated glomerular filtration rate (eGFR) among chronic kidney disease (CKD) patients based on age, sex, and Rh factor. A total of 100 adult patients (≥18 years) with clinically diagnosed CKD (Stages 1–5) were included. Result: In this study of 100 CKD patients, the majority were over 60 years of age (45%) and male (59%), with most being Rh positive (86%). A clear decline in mean eGFR was observed with increasing age, from 58.9 mL/min/1.73 m² in the 18–40 age group to 33.7 mL/min/1.73 m² in those over 60. Females had a slightly higher mean eGFR than males, and Rh-negative patients had lower mean eGFR compared to Rh-positive patients. Most patients were in CKD stages 3b (26%) and 4 (28%), with advanced stages more prevalent in older individuals. Conclusion: This study found that eGFR declined with age, especially after 60 years. Females had slightly higher mean eGFR than males, though not significant. Rh-negative patients showed lower eGFR than Rh-positive, indicating a potential association needing further study.