Clinical and Biochemical Profile of Patients with Chronic Kidney Disease in a Tertiary Care Hospital

Open Access

Abstract

Background: Chronic kidney disease (CKD) is characterized by the gradual worsening of renal failure and various clinical, biochemical, cardiovascular and radiological malfunctions. The description of these results is significant to fully evaluate patients who are affected with CKD. Objective: To consider the clinical and biochemical characteristics of patients with chronic kidney disease who visited a tertiary care hospital. Methods & Materials: The current cross-sectional study was carried out at the Department of Medicine, Shaheed Tajuddin Ahmad Medical College, Gazipur, Bangladesh between June 2022 and December 2022 in a sample of 100 patients with CKD. Demographic features, clinical observation, vital signs, photos of biochemical parameters, serum electrolytes, electrocardiographic observations and radiological observations were evaluated. Descriptive statistics were used to analyze data. Results: The mean age of the participants was 46.6±8.3 years, and 74.0% were male. The mean duration of CKD was 20.7±18.1 months. The mean serum creatinine, blood urea nitrogen and estimated glomerular filtration rate were 2.9+1.3 mg/dl, 23.0+5.8 mg/dl and 25.0+14.7 mL/min/1.73 m 2 respectively. The mean serum albumin was 2.9100.4g/dl and the mean total protein was 6.4100.2g/dl. The mean serum sodium, potassium, chloride and bicarbonate levels were 137.8±5.5, 4.4±0.8, 98.2±2.9 and 25.0±2.2 mmol/L, respectively. In 61.0% ECG was normal, and sinus tachycardia was present in 27.0%. The ultrasonography revealed that bilateral renal parenchymal disease was identified in 89.0% of patients. Conclusion: CKD patients showed significant renal abnormalities along with biochemical, nutritional, electrolytes, cardiovascular and radiologic abnormalities. Extensive clinical and laboratory assessment can contribute to a better description of the overall disease profile for the tertiary-care CKD populations.