Vol. 7 No. 01 (2023)
Original Article

Expression of E-Cadherin and its Association with Histological Prognostic Parameters of Breast Carcinoma

Full Article

Afroza Ferdous
Senior Clinical Pathologist, Department of Pathology, Mugda Medical College Hospital, Dhaka, Bangladesh
Mohammed Shahed Ali Jinnah
Professor & Director, National Institute of Laboratory Medicine & Referral Center (NILMRC), Dhaka, Bangladesh
Saiyeda Sinthia Karim
Associate Professor, Department of Pathology, Dhaka Medical College Hospital, Dhaka, Bangladesh
Mohammad Tanvir Hasan
Associate Professor, Department of Surgery, US-Bangla Medical College Hospital, Narayangonj, Bangladesh
Md Shahriar Ferdous
Assistant Surgeon, Natore Sadar Hospital, Natore, Bangladesh

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Introduction: Breast cancer stands as the foremost cause of morbidity and mortality among females globally, including Bangladesh. Metastasis development is a crucial prognostic factor in invasive breast cancer, often requiring systemic treatment. The aberrant expression of adhesion-related antigens on tumor cells strongly indicates the tumor's metastatic potential, leading to a poor prognosis for the patient. This study aimed to assess the expression of E-Cadherin and its association with histological prognostic parameters of breast carcinoma. Methods and materials: This cross-sectional study was conducted at the Department of Pathology, Dhaka Medical College, Dhaka, Bangladesh from March 2020 to February 2022. A total of 41 patients diagnosed with invasive breast carcinoma of no specific type were included in the study using convenient sampling. SPSS Version 23.0 was used for data analysis. Results: In this study, most patients exhibited E-Cadherin negativity, significantly associated with histological grading, increased tumor size (p = 0.024), more metastasized lymph nodes (p = 0.032), and triple-negative breast cancer (p = 0.011). Loss of E-Cadherin expression in both core needle biopsy and mastectomy samples showed a significant association with higher tumor grade (p = 0.009 and 0.028, respectively). Conclusion: Assessing E-Cadherin expression may be crucial in evaluating tumor aggressiveness and planning treatment modalities.


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Published 10-02-2024


  • E-Cadherin expression,
  • Histological prognostic parameters,
  • Breast carcinoma,
  • Core biopsy,
  • Mastectomy,
  • Cancer
  • ...More

How to Cite

Ferdous A, Jinnah MSA, Karim SS, Hasan MT, Ferdous MS. Expression of E-Cadherin and its Association with Histological Prognostic Parameters of Breast Carcinoma. Planet (Barisal) [Internet]. 2024 Feb. 10 [cited 2024 Jul. 25];7(01):370-8. Available from: https://bdjournals.org/index.php/planet/article/view/440