Vol. 7 No. 01 (2023)
Original Article

Expression of E-Cadherin and its Association with Histological Prognostic Parameters of Breast Carcinoma

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Afroza Ferdous
Senior Clinical Pathologist, Department of Pathology, Mugda Medical College Hospital, Dhaka, Bangladesh
Mohammed Shahed Ali Jinnah
Professor & Director, National Institute of Laboratory Medicine & Referral Center (NILMRC), Dhaka, Bangladesh
Saiyeda Sinthia Karim
Associate Professor, Department of Pathology, Dhaka Medical College Hospital, Dhaka, Bangladesh
Mohammad Tanvir Hasan
Associate Professor, Department of Surgery, US-Bangla Medical College Hospital, Narayangonj, Bangladesh
Md Shahriar Ferdous
Assistant Surgeon, Natore Sadar Hospital, Natore, Bangladesh

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Abstract

Introduction: Breast cancer stands as the foremost cause of morbidity and mortality among females globally, including Bangladesh. Metastasis development is a crucial prognostic factor in invasive breast cancer, often requiring systemic treatment. The aberrant expression of adhesion-related antigens on tumor cells strongly indicates the tumor's metastatic potential, leading to a poor prognosis for the patient. This study aimed to assess the expression of E-Cadherin and its association with histological prognostic parameters of breast carcinoma. Methods and materials: This cross-sectional study was conducted at the Department of Pathology, Dhaka Medical College, Dhaka, Bangladesh from March 2020 to February 2022. A total of 41 patients diagnosed with invasive breast carcinoma of no specific type were included in the study using convenient sampling. SPSS Version 23.0 was used for data analysis. Results: In this study, most patients exhibited E-Cadherin negativity, significantly associated with histological grading, increased tumor size (p = 0.024), more metastasized lymph nodes (p = 0.032), and triple-negative breast cancer (p = 0.011). Loss of E-Cadherin expression in both core needle biopsy and mastectomy samples showed a significant association with higher tumor grade (p = 0.009 and 0.028, respectively). Conclusion: Assessing E-Cadherin expression may be crucial in evaluating tumor aggressiveness and planning treatment modalities.

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Published 10-02-2024

Keywords

  • E-Cadherin expression,
  • Histological prognostic parameters,
  • Breast carcinoma,
  • Core biopsy,
  • Mastectomy,
  • Cancer
  • ...More
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How to Cite

1.
Ferdous A, Jinnah MSA, Karim SS, Hasan MT, Ferdous MS. Expression of E-Cadherin and its Association with Histological Prognostic Parameters of Breast Carcinoma. Planet (Barisal) [Internet]. 2024 Feb. 10 [cited 2024 Jul. 25];7(01):370-8. Available from: https://bdjournals.org/index.php/planet/article/view/440