Vol. 7 No. 01 (2023)
Original Article

Clinicopathological Features and Predictors of Lupus Nephritis Patients — A Study in a Tertiary Care Hospital in Bangladesh

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Farhana Faruque
Assistant Registrar, Department of Nephrology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh
Naylla Islam
Junior Consultant, Department of Medicine, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh
S M Sufi Shafi-Ul Bashar
Registrar, Department of Orthopaedics Surgery, National Institute of Traumatology & Orthopedic Rehabilitation (NITOR), Dhaka, Bangladesh
Shahryar Waheed
Associate Professor, Department of Nephrology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh
Nayan Ranjan Sarkar
Associate Professor, Department of Nephrology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh
Md Ismail Hossain
Associate Professor, Department of Nephrology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh
A S M Sohel Bin Sayeed
Junior Consultant, Department of Nephrology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh

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Abstract

Introduction: Lupus nephritis (LN) represents a severe manifestation of systemic lupus erythematosus, and its clinicopathological findings significantly impact the overall disease prognosis. Unfortunately, there is a scarcity of data on lupus nephritis (LN) in Bangladeshi patients in the existing literature. Aim of the study: This study aimed to assess the clinicopathological features and predictors of lupus nephritis patients in Bangladesh. Methods and materials: This cross‑sectional study was conducted at the Department of Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh from January 2023 to July 2023. The study included a total of 30 lupus nephritis patients, selected through purposive sampling. All data were analyzed by using the SPSS version 23.0 program. Results: In this study, the majority of participants (53%) belonged to the ≤24 years age group, with 77% being female. Regarding the classification of lupus nephritis according to the International Society of Nephrology/Renal Pathology Society (ISN/RPS), the majority (53%) fell into class IV. Remarkably, all of our participants (100%) exhibited a SLEDAI 2K score of ≥20. Conclusion: Among the Bangladeshi population, lupus nephritis is more prevalent in younger individuals and females. In the majority of lupus nephritis cases, ISN/RPS score IV is observed, and there is a higher frequency of having a SLEDAI 2K score of ≥20. In addition to the ISN/RPS score, SLEDAI 2K scores can be regarded as another reliable diagnostic tool for evaluating lupus nephritis.

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Published 10-02-2024

Keywords

  • Lupus Nephritis,
  • LN,
  • Systemic lupus erythematosus,
  • SLEDAI 2K score,
  • ISN,
  • RPS classification
  • ...More
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How to Cite

1.
Faruque F, Islam N, Bashar SMSS-U, Waheed S, Sarkar NR, Hossain MI, Sayeed ASMSB. Clinicopathological Features and Predictors of Lupus Nephritis Patients — A Study in a Tertiary Care Hospital in Bangladesh. Planet (Barisal) [Internet]. 2024 Feb. 10 [cited 2024 Jul. 25];7(01):138-45. Available from: https://bdjournals.org/index.php/planet/article/view/415