Liver damage of OPC poisoning patient in Patuakhali Medical College Hospital, Patuakhali

Abstract

Background: Organophosphorus (OP) pesticide poisoning is widespread in the developing world .The liver is the main organ that metabolizes various compounds including toxins, chemicals and drugs and eventually excretes from the body. Objective: To find out the level of liver enzymes among the organophosphorus compound poisoning. Methods and Materials: A cross-sectional study conducted from June 2018 to July 2020 in Department of Medicine, Patuakhali Medical College Hospital. Total 51 patients in whom a provisional diagnosis of OPC poisoning was made based on the patient’s clinical presentation/history as recorded from the patient’s attendant/details of poison containers were included in the study. P values <0.05 was considered as statistically significant. Results: Female patients were predominant 29(56.9%). The most common OP compound found to be abused among this study group was chlorpyrifos in 24 (47.1%) patients, which is an agricultural pesticide. Around 17 (33.3%) cases were found with abuse of methyl parathion (folidol), the cough syrup. AST and RBS were statistically significant compared between low and normal level of cholinesterase. Out of 51 patients, 33(64.7%) were discharge, 14(27.5) were DORB, 2(3.9%) were death, 1(2.0%) absconded and 1(2.0%) transfer out. Conclusion: This study observed young age and female patients were predominant. Majority patients were decreased serum cholinesterase level and blood sugar level was raised in the majority of cases with AST enzymes. Significant relation was found serum AST enzymes and RBS level in OP poisoning patients.