Association of Biochemical Markers between Hepatitis C Virus and Diabetes Mellitus among Bangladeshi Male

Abstract

Introduction: Diabetes is regarded to be one of the extrahepatic diseases associated with HCV infection. People with diabetes had a higher chance of exposure to HCV. In addition to insulin resistance and glucose intolerance, liver cirrhosis may also result in insulin resistance and glucose intolerance. Objective: The aim of the study is to assess the association of Biochemical Biomarker between Hepatitis C virus and Diabetes Mellitus among Bangladeshi Male. Methods: A total of 197 males suspected of having HCV were included in the study, 111 of whom tested positive through ELSIA and PCR. The analysis indicates that there were 45 (22.8%) HCV-only (without diabetes) participants, 66 (33.6%) HCV-plusdiabetes patients, and 86 (43.7%) diabetes only patients (negative for HCV ELISA). Biochemical tests of all three groups were performed to determine liver, diabetic and lipid profiles. Results: ALT levels were higher in individuals with HCV only and HCV + diabetes than in patients with diabetes alone. ALT was significant among HCV, HCV + diabetes and diabetes only participants (p ≤ 0.005) whereas ALT was highly significant (p ≤ 0.001). AST showed significant to HCV+ diabetes individuals (p ≤ 0.005). Patients with HCV+ diabetes has higher HbA1C, BGF, and BGR levels than patients with diabetes alone. Individual with HCV only showed no statistically significant with HbA1c, BGF and BGR (P> 0.005).For the HCV only group cholesterol differences were extremely significant (P≤ 0.001). For all three patient groups, HDL was found to be non-significant (P > 0.005). Conclusion: Diabetes is significantly associated with hepatitis C virus infection. In this association, serum ALT, triglyceride, and LDL are significant factors. Additional research should shed information on how to enhance the clinical care of diabetic patients with HCV infection.