Serum Vitamin D level and its Relationship with HbA1c in Type 2 Diabetes mellitus patients – A Comparative Study

Open Access

Abstract

Background: Diabetes mellitus is a non-communicable disease caused by multiple factors leading to insulin deficiency and insulin resistance. Vitamin D is responsible for calcium homeostasis. Vitamin D has an important role and is supposed to be a risk factor in the development & pathogenesis of type 2 diabetes mellitus by affecting either insulin sensitivity or beta cell function, or both. Objectives: The study was aimed to establish a relationship between serum vitamin D level and its effect on HbA₁c in type 2 diabetes mellitus patients. Methods & Material: This comparative study was carried out among equal number of diabetic and nondiabetic participants in the department of physiology, Rajshahi Medical college, Rajshahi. Serum vitamin D and HbA₁c was measured among the two groups. Data was analyzed by computer using the SPSS 24. Result: The mean BMI was 26.84 ± 3.25 & 26.79 ± 2.98 kg/m² in diabetic & non-diabetic group participants respectively. The serum vitamin D level was significantly (p < 0.001) lower in diabetic group (26.96 ± 8.54) as compared to non-diabetic group (36.51 ± 10.43). In type 2 diabetic participants a negative correlation was documented between HbA₁c and serum vitamin D level and it was statistically significant. Conclusion: Hypovitaminosis D was observed in type 2 diabetes mellitus patients and there was an inverse relationship between serum vitamin D and HbA₁c level.