Relationship of Microalbuminuria with HbA1c and Other Renal Function Parameters in Type 2 Diabetic Post Menopausal Women

Open Access

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a growing global health concern, with Bangladesh projected to rank 8th in adult diabetes prevalence by 2030 [1–4]. Microalbuminuria, an early marker of diabetic nephropathy linked to poor glycemic control, predicts renal and cardiovascular complications [5,6]. This study aims to assess the correlation between microalbuminuria, glycemic control, and renal function parameters in postmenopausal women with T2DM. Aim of the study: The aim of the study was to evaluate the association between microalbuminuria, HbA1c levels, and renal function parameters in postmenopausal women with type 2 diabetes at DMCH. Methods & Materials: This cross-sectional study at the Department of Biochemistry, Dhaka Medical College, Dhaka, Bangladesh (July 2014–June 2015) included 100 postmenopausal women with type 2 diabetes from the endocrine outpatient department. Blood and urine samples were analyzed for glucose, HbA1c, albumin, creatinine, microalbuminuria, and ACR. Data were processed using SPSS v21; p<0.05 was considered significant. Results: Among 100 postmenopausal women with T2DM, 78% had microalbuminuria. All patients with diabetes >5 years and 94.4% with hypoalbuminemia were microalbuminuria positive. Significant correlations were found with ACR (r=0.997), HbA1c (r=0.75), FBS (r=0.717), S. creatinine (r=0.694), S. albumin (r=–0.750), and U. creatinine (r=–0.762) (p=0.001). Conclusion: Microalbuminuria is common in diabetic postmenopausal women in Bangladesh, and early screening can help prevent diabetic complications and chronic kidney disease.