Clinical Outcomes of Homeo pathic Constitutional Treatment Added to Long-Term Allopathic Therapy in Parkinson’s Disease and Bone Degeneration - Cross-Validation of the Veredas Protocol

Open Access

Abstract

Objectives: To assess the clinical effects of adding individualized homeopathic treatment, based on the Effective Dose 100% (DE100) model, to ongoing allopathic treatment in patients with Parkinson’s disease or degenerative bone disorders. The study also explores the use of the Veredas App as a tool for personalized dose management. Methods: In this mixed-methods study, 35 patients previously treated with allopathic medications (mean duration: 60.5 months) received a one-month course of constitutional homeopathic medicines prescribed using DE100 logic. Symptoms were scored on a 0–4 scale in real time, using the Veredas mobile application to identify each patient's worst (PM) and best (MM) daily moments. Symptom patterns were recorded over 28 days. Eleven cases were also analyzed via video to compare responses to allopathic (DE50) and homeopathic (DE100) treatment phases. Results: Previously published outcomes using the Veredas Protocol showed symptom improvements of 60.2% (chronic pain), 91% (Parkinson’s), and 85% (emotional/mental health). In this study, 57.7% clinical improvement was observed after adding homeopathy. Patient self-assessments via the app showed 77% concordance with independent video analysis. While DE50-based treatments yielded limited changes, DE100-guided dosing achieved similar or greater results in one month using potencies averaging CH15. Conclusions: Although this study was not designed to compare DE50 and DE100 as conceptual frameworks, the findings suggest that individualized timing of dose administration may play a key role in clinical improvement. The Veredas App shows promise as a precision-prescribing tool. Further studies should explore the influence of dosing logic on treatment efficacy, independent of the medication paradigm.