Evaluation Of Coriandrum Sativum Seed Extracts As Potential Antimicrobial Agents Against Certain Common Pathogens

Open Access

Abstract

Background: Antimicrobial resistance (AMR) poses a major global health threat, necessitating alternative therapeutic agents. Plant-derived compounds offer promising solutions, and Coriandrum sativum (coriander) has traditional medicinal uses against infections. Objective: To evaluate the antibacterial activity of aqueous and methanolic extracts of Coriandrum sativum seeds against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Methods & Materials: This experimental study was conducted at Mymensingh Medical College, Bangladesh, from January to December 2025. Disc diffusion and broth dilution methods were used to evaluate aqueous (ACSE) and methanolic (MCSE) seed extracts against standard bacterial strains (ATCC 25923, 25922, 27853). Zone of inhibition (ZOI) and minimum inhibitory concentration (MIC) were determined. Ciprofloxacin served as the reference antibiotic. Results: ACSE at 1000 mg/ml produced ZOI of 17 mm, 15 mm, and 23 mm against S. aureus, E. coli, and P. aeruginosa, respectively. MCSE showed corresponding ZOI of 17 mm, 16 mm, and 23 mm. MIC values for ACSE were 800, 800, and 700 mg/ml; for MCSE were 700, 750, and 700 mg/ml against the three organisms, respectively. Ciprofloxacin MIC ranged from 0.5 to 1 µg/ml. Conclusion: Coriandrum sativum seed extracts demonstrate significant, broad-spectrum antibacterial activity. Methanolic extracts showed slightly superior efficacy. These findings support traditional medicinal use and warrant further investigation for developing plant-based antimicrobial therapies.