Indications for the Usage of Proton Pump Inhibitors in Medicine,Surgery, and Gastroenterology Ward of Dhaka Medical College Hospital

Résumé

Introduction: The landscape of treating acid-related diseases has undergone a profound transformation with the introduction of proton pump inhibitors (PPIs) into clinical practice.The strong evidence supporting PPI efficacy and a favorable safety profile has led to the overuse of these drugs both in hospitals and in primary care settings. This study aimed to assess appropriateness in the indication of proton pump inhibitors in medicine, surgery, and gastroenterology wards of Dhaka Medical College Hospital. Methods & Materials: This cross-sectional observational study was conducted at the Department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka, from July 2019 to June 2020. Data were analyzed using descriptive statistics. Analysis of data was carried out by using Statistical Package for Social Science (SPSS) 22.0 for Windows. Result: Among 521 patients, who were prescribed PPIs, 255 (48.9%) patients were given PPIs for appropriate indications, whereas in 266 (51.1%) patients indications were not appropriate for prescribing PPIs. There was a significant difference (p<0.05) inappropriateness in the usage of PPIs in different departments of Dhaka Medical College Hospital. Among the three departments, for prescribing PPIs appropriate indications were followed mostly in the gastroenterology department (59; 59.6%), followed by the medicine department (93; 49.5%), and were lowest (103; 44%) in the surgery department. Conclusion: This study concludes that most of the patients' PPI prescriptions do not follow appropriate indications recommended by reference guidelines and inappropriate usage is most common in the surgery department, followed by the medicine department.