Incidence of Uropathogens and their Antibiotic Resistance

Abstract

Introduction: Urinary tract infection is the most common human infection. Resistance of uropathogen to antibiotic is now a global problem. E. coli is the most common organism. Variation in resistance pattern of different antibiotic are known to occur in different geographic areas as well as in the same country. Given this background the aim of this study was to identify common uropathogens and their résistance profile among the patient at the OPD of Sheikh Sayera Khatun Medical College, Gopalganj. Materials and method: Appropriate urine specimens of all suspected cases of UTI are processed in the laboratory for detection of significant bacteriuria. Bacterial uropathogens isolated were identified by standard biochemical tests and antibiotic susceptibility test to antibiotics was carried out on them by using Kirby-Bauer disc diffusion technique. Results: Among 77 uropathogens, Escherichia coli accounted for 73 (94.80%) of all isolate and others are Pseudomonas 3(3.89%) and Klebsiella (1.29%) respectively. E. coli showed sensitivity to Meropenem-73(100%), netilmycins-71(97.25%), amoxicillin-clavulanic acid-67(91.77%), gentamycin-64(87.66%), nitrofuantoin-63(86.29), levofloxacin-(83.55%) and ceftazidime-59 (80.81%) respectively. In contrast, E. coli. were resistant to Nalidixic acid- 62(84.93%), Cefachlor- 62(84.93%), Cefuroxime- 47(64.38), Cefixime- 45(61.64%) and ciprofloxacin- 34(46.57%). Conclusion: Knowledge about uropathogens and local antibiotic resistance is needed to determine the appropriate empirical antibiotic therapy and overcoming drug resistance.